Top ceramide Articles in Dermatology

Link between plasma ceramides, inflammation and insulin resistance: association with serum IL-6 concentration in patients with coronary heart disease
Diabetologia - Clinical and Experimental Diabetes and Metabolism, 08/18/2009

Mello VDFD et al. – The authors' results strongly suggest that the link between ceramides, IR and inflammation is related to the inflammatory ... Ceramides may contribute to the induction of inflammation involved in IR states that frequently coexist with CHD. [more...]

Comparison of Lipid and Fatty Acid Composition of the Liver, Subcutaneous and Intra-abdominal Adipose Tissue, and Serum
Obesity, 10/09/2009

Kotronen A et al. – Ceramides may mediate saturated fat–induced insulin resistance, but there are no data comparing ceramide concentrations between human tissues. The human liver contains higher concentrations of ceramides and saturated free fatty acids than either SCfat or [more...]

Novel ceramides from aerial parts of Saussurea involucrata Kar. et. Kir
Archives of Pharmacal Research, 10/15/2009

Wu L et al. – The results suggested that this class of ceramides may have potential as an antitumor agent. [more...]

Synthesis of sphingosine is required for oxidative stress-induced apoptosis of photoreceptors
Investigative Ophthalmology and Visual Science, 10/15/2009

Abrahan C et al. – These results suggest that oxidative stress enhances formation of ceramide and its subsequent breakdown to Sph; ceramide and/or Sph would then trigger photoreceptor apoptosis. Preventing Sph synthesis or promoting its phosphorylation to S1P [more...]

The role of ceramide in major depressive disorder
European Archives of Psychiatry and Clinical Neuroscience, 11/12/2009

Kornhuber J et al. – Major depression is a severe mood disorder with a lifetime prevalence of more than 10%. The pharmacokinetic hypothesis claims that a slow accumulation of antidepressant drugs by acid trapping mainly into lysosomes is ... target mediates the antidepressant effects. The lysosomal lipid metabolizing enzyme acid sphingomyelinase (ASM) cleaves sphingomyelin into ceramide and phosphorylcholine. [more...]

Skeletal Muscle Lipogenic Protein Expression Is Not Different between Lean and Obese Individuals; A Potential Factor in Ceramide Accumulation
Journal of Clinical Endocrinology and Metabolism, 10/29/2009

Thrush AB et al. – In muscle of obese humans there is an insufficient lipogenic response to the lipid oversupply, allowing more FA to be stored as reactive lipid species, particularly ceramide, potentially contributing to subsequent [more...]

Insulin Resistance is Associated with Higher Intramyocellular Triglycerides in Type I but not Type II Myocytes Concomitant with Higher Ceramide Content
Diabetes, 11/05/2009

Coen PM et al. – Human skeletal muscle insulin resistance is related to greater IMTG content in type I, but not type II myocytes, to greater ceramide content, and to alterations in gene expression associated with [more...]

Are the new moisturizers more effective?
Current Opinion in Pediatrics, 08/26/2009

is overwhelming, and most patients would like their physicians to recommend specific products. The authors attempt to provide a review of the newer products available, with special emphasis on those products that contain ceramides. [more...]

Common cosmeceuticals
Clinics in Dermatology, 08/25/2009

presentation , focuses on only 10 types of cosmeceutical agents: five vitamins (A, B3, C, E, panthenol), peptides, hydroxyl acids, sugar amines, ceramides, and metals. In particular, this contribution concentrates on those materials for which there are available clinical data that support a reported [more...]

Down regulation of membrane-bound Neu3 constitutes a new potential marker for childhood acute lymphoblastic leukemia and induces apoptosis suppression of neoplastic cells
International Journal of Cancer, 09/21/2009

compared with cells from healthy controls Induced overexpression of Neu3 in the ALL-cell line, MOLT-4, led to a significant increase of ceramide (+66%) and to a parallel decrease of lactosylceramide (-55%) These events strongly guided lymphoblasts to apoptosis, as we assessed by the [more...]