Top basal cell Articles in Dermatology

High ACAT1 expression in estrogen receptor negative basal-like breast cancer cells is associated with LDL-induced proliferation
Breast Cancer Research and Treatment, 11/04/2009

Antalis CJ et al. – A greater ability to take up, store and utilize exogenous cholesterol confers a proliferative advantage to basal-like ER? breast cancer cells. Differences in lipid uptake ... in ER? basal-like MDA-MB-231 and MDA-MB-436 breast cancer cell lines Results Both triacylglycerol and cholesteryl ester (CE) concentrations were higher in the ER? cells, but the ability to synthesize CE distinguished the two types of breast cancer cells Higher ... ER? compared to ER+ cells The differences corresponded to greater mRNA and protein levels of acyl-CoA:cholesterol acyltransferase 1 (ACAT1), higher ACAT activity, higher caveolin-1 protein levels, greater LDL uptake, and lower de novo cholesterol synthesis in ER? cells Human LDL ... cells, but had little effect on proliferation of ER+ MCF-7 cells The functional significance of these findings was demonstrated by the observation that the ACAT inhibitor CP-113,818 reduced proliferation of breast cancer cells, and specifically reduced LDL-induced proliferation of ER? cells [more...]

Cytokeratin expression patterns in multiple infundibulocystic basal cell carcinoma
Journal of Cutaneous Pathology, 10/28/2009

Hida T et al. – Infundibulocystic basal cell carcinoma (IBCC) is a variant of basal cell carcinoma. Sporadic cases usually represent a solitary tumor and multiple IBCC is rare. There have been no reports in ... immunohistochemically. [more...]

Role of GPR30 in the mechanisms of tamoxifen resistance in breast cancer MCF-7 cells
Breast Cancer Research and Treatment, 11/20/2009

Ignatov A et al. – Tamoxifen is the most frequently used anti-hormonal drug for treatment of women with hormone-dependent breast cancer. The aim of this study is to investigate the mechanism of tamoxifen ... li> MCF-7 cells continuously exposed to tamoxifen for 6 months to induce resistance to inhibitory effect of tamoxifen Results Tamoxifen-resistant cells (TAM-R) exhibited enhanced sensitivity to 17-ß-estradiol and GPR30 agonist, G1, when compared to parental cells cells, tamoxifen was able to stimulate cell growth and MAPK phosphorylation Effects abolished by EGFR inhibitor AG1478, GPR30 anti-sense oligonucleotide, and selective c-Src inhibitor PP2 Only EGFR basal expression slightly elevated in TAM-R cells, whereas GPR30 expression and basal ... of Akt and MAPK remained unchanged when compared to parental cells Estrogen treatment significantly increased GPR30 translocation to the cell surface, was stronger in TAM-R cells Continuous treatment of MCF-7 cells with GPR30 agonist G1 mimics long-term treatment with tamoxifen and [more...]

Big Bad BCCs: craniofacial resection and reconstruction for atypical basal cell carcinoma
Journal of Plastic, Reconstructive & Aesthetic Surgery, 11/03/2009

Fattah A et al. – Basal cell carcinoma is the most common malignancy of the body and most frequently occurs in the head and neck. ‘Problematic aggressive’ BCCs are either frequently recurrent, often ... features and outcomes of ‘problematic aggressive’ craniofacial BCCs are reported that required craniofacial resection and reconstruction with microsurgical free flap cover, and a re–evaluation of the care pathway for these uncommon presentations. [more...]

Induction of MMP-2 at the interface between epithelial cells and fibroblasts from human periodontal ligament
Journal of Periodontal Research, 11/12/2009

Shimonishi M et al. – These findings indicate that putative epithelial rests of Malassez cells stimulate the production of MMP–2 in human periodontal ligament fibroblasts. Up ... expressed in epithelial rests of Malassez cells can degrade matrix molecules, such as type IV collagen, in the basal membrane between putative epithelial rests of Malassez cells and human periodontal ligament fibroblasts. [more...]

Prognostic impact of ALDH1 in breast cancer: A story of stem cells and tumor microenvironment
Breast Cancer Research and Treatment, 11/20/2009

Resetkova E et al. – In this study, we sought to examine the prognostic relevance of ALDH1, a putative cancer stem cell marker, by immunohistochemistry. The novel finding in this study is that tumor ... stem/progenitor cells in human breast tumors.Methods 4 cohorts analyzed included adjuvantly treated series of 245 invasive cancers, a neoadjuvantly treated series of 34 cases, and 2 series of 58 and 40 triple negative cases, respectively Both tumor cell and stromal ... li> Results Tumor cell ALDH1 expression significantly correlated only with basal-like and HER2 tumor types in adjuvant series and tumor grade in neoadjuvant cohort No significant enrichment for ALDH1 positive cells observed in postneoadjuvant therapy specimens compared [more...]

Photodynamic therapy with methyl aminolevulinate for primary nodular basal cell carcinoma: results of two randomized studies
International Journal of Dermatology, 11/12/2009

Foley P et al. – Although longer follow–up studies are required, these promising data indicate the potential of topical MAL PDT as a noninvasive treatment ... photodermatology,dermatology [more...]

Basal cell adenoma of the parotid gland: a clinicopathological study of nine cases--basal cell adenoma versus pleomorphic adenoma and Warthin's tumor
European Archives of Oto-Rhino-Laryngology, 11/17/2009

Kawata R et al. – There were no significant differences in the duration of surgery, the blood loss, and the incidence of transient facial [more...]

Alpha7 Nicotinic Acetylcholine Receptor Regulates Airway Epithelium Differentiation by Controlling Basal Cell Proliferation
American Journal of Pathology, 10/06/2009

Maouche K et al. – These findings suggest that alpha7 nAChR is a key regulator of the plasticity of the human airway epithelium by controlling basal cell proliferation and differentiation pathway and is involved in [more...]

Basal Cell Carcinoma of the Nipple-Areola Complex
Dermatologic Surgery, 11/17/2009

Ferguson M et al. – The optimal treatment of this condition should be local excision, but patients with this condition should be followed up for primary site recurrence and axillary metastasis, because there is greater incidence than with BCC ... at other anatomical sites. [more...]